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Elizabeth Head

Address800 South Limestone Street
204 Sanders Brown Ctr
Lexington KY 405360230
Phone8592183172
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pop V, Sorensen DW, Kamper JE, Ajao DO, Paul Murphy M, Head E, Hartman RE, Badaut J. Early brain injury alters the blood-brain barrier phenotype in parallel with ß-amyloid and cognitive changes in adulthood. J Cereb Blood Flow Metab. 2013 Feb; 33(2):205-14. PMID: 23149553.
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    2. Whitcomb DC, Larusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS, Guda NM, Orlichenko L. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012 Nov 11; 44(12):1349-54. PMID: 23143602.
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    3. Head E, Silverman W, Patterson D, Lott IT. Aging and down syndrome. Curr Gerontol Geriatr Res. 2012; 2012:412536. PMID: 22844278.
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    4. Tansley G, Holmes DT, Lütjohann D, Head E, Wellington CL. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. Curr Gerontol Geriatr Res. 2012; 2012:179318. PMID: 22649448.
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    5. Saing T, Dick M, Nelson PT, Kim RC, Cribbs DH, Head E. Frontal cortex neuropathology in dementia pugilistica. J Neurotrauma. 2012 Apr 10; 29(6):1054-70. PMID: 22017610.
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    6. Head E, Murphey HL, Dowling AL, McCarty KL, Bethel SR, Nitz JA, Pleiss M, Vanrooyen J, Grossheim M, Smiley JR, Murphy MP, Beckett TL, Pagani D, Bresch F, Hendrix C. A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease. J Alzheimers Dis. 2012 Jan 1; 32(4):1029-42. PMID: 22886019.
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    7. Barone E, Mancuso C, Di Domenico F, Sultana R, Murphy MP, Head E, Butterfield DA. Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. J Neurochem. 2012 Jan; 120(1):135-46. PMID: 22004509.
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    8. Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP. BACE2 expression increases in human neurodegenerative disease. Am J Pathol. 2012 Jan; 180(1):337-50. PMID: 22074738.
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    9. Mariappan P, Finney SM, Head E, Somani BK, Zachou A, Smith G, Mishriki SF, N'Dow J, Grigor KM. Good quality white-light transurethral resection of bladder tumours (GQ-WLTURBT) with experienced surgeons performing complete resections and obtaining detrusor muscle reduces early recurrence in new non-muscle-invasive bladder cancer: validation across time and place and recommendation for benchmarking. BJU Int. 2012 Jun; 109(11):1666-73. PMID: 22044434.
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    10. Hunter MP, Nelson M, Kurzer M, Wang X, Kryscio RJ, Head E, Pinna G, O'Bryan JP. Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Neuroreport. 2011 Oct 26; 22(15):767-72. PMID: 21876463.
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    11. Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. PLoS One. 2011; 6(10):e24777. PMID: 22046234.
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    12. Dowling AL, Head E. Antioxidants in the canine model of human aging. Biochim Biophys Acta. 2012 May; 1822(5):685-9. PMID: 22005070.
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    13. Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H, Lott IT, Schmitt FA, Butterfield DA, Head E. Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochim Biophys Acta. 2012 Feb; 1822(2):130-8. PMID: 22009041.
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    14. Butterfield DA, Barone E, Di Domenico F, Cenini G, Sultana R, Murphy MP, Mancuso C, Head E. Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. Int J Neuropsychopharmacol. 2012 Aug; 15(7):981-7. PMID: 21767440.
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    15. Martin SB, Cenini G, Barone E, Dowling AL, Mancuso C, Butterfield DA, Murphy MP, Head E. Coenzyme Q10 and cognition in atorvastatin treated dogs. Neurosci Lett. 2011 Aug 26; 501(2):92-5. PMID: 21763754.
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    16. Lott IT, Doran E, Nguyen VQ, Tournay A, Head E, Gillen DL. Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation. Am J Med Genet A. 2011 Aug; 155A(8):1939-48. PMID: 21739598.
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    17. Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. An amyloid ß42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiol Aging. 2012 Aug; 33(8):1522-32. PMID: 21546126.
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    18. Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathol. 2011 May; 121(5):571-87. PMID: 21516511.
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    19. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. PMID: 21460841.
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    20. Head E, Doran E, Nistor M, Hill M, Schmitt FA, Haier RJ, Lott IT. Plasma amyloid-ß as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. J Alzheimers Dis. 2011; 23(3):399-409. PMID: 21116050.
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    21. Barone E, Cenini G, Di Domenico F, Martin S, Sultana R, Mancuso C, Murphy MP, Head E, Butterfield DA. Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacol Res. 2011 Mar; 63(3):172-80. PMID: 21193043.
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    22. Kayed R, Canto I, Breydo L, Rasool S, Lukacsovich T, Wu J, Albay R, Pensalfini A, Yeung S, Head E, Marsh JL, Glabe C. Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aß oligomers. Mol Neurodegener. 2010; 5:57. PMID: 21144050.
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    23. Vasilevko V, Passos GF, Quiring D, Head E, Kim RC, Fisher M, Cribbs DH. Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy. Ann N Y Acad Sci. 2010 Oct; 1207:58-70. PMID: 20955427.
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    24. Head E. Neurobiology of the aging dog. Age (Dordr). 2011 Sep; 33(3):485-96. PMID: 20845082.
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    25. Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. PLoS One. 2010; 5(9):e12538. PMID: 20838618.
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    26. Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW. Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. J Neurosci. 2010 Jul 21; 30(29):9831-9. PMID: 20660265.
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    27. Vasilevko V, Pop V, Kim HJ, Saing T, Glabe CC, Milton S, Barrett EG, Cotman CW, Cribbs DH, Head E. Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiol Dis. 2010 Sep; 39(3):301-10. PMID: 20451612.
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    28. Fahnestock M, Marchese M, Head E, Pop V, Michalski B, Milgram WN, Cotman CW. BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiol Aging. 2012 Mar; 33(3):546-54. PMID: 20447733.
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    29. Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. Aß aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiol Aging. 2012 Jan; 33(1):108-20. PMID: 20434811.
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    30. Coskun PE, Wyrembak J, Derbereva O, Melkonian G, Doran E, Lott IT, Head E, Cotman CW, Wallace DC. Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. J Alzheimers Dis. 2010; 20 Suppl 2:S293-310. PMID: 20463402.
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    31. Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H, Kryscio RJ, Lin Y, Barrett E, Head E. Changes in cognition and amyloid-ß processing with long term cholesterol reduction using atorvastatin in aged dogs. J Alzheimers Dis. 2010; 22(1):135-50. PMID: 20847439.
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    32. Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP. Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. J Alzheimers Dis. 2010; 20(2):637-46. PMID: 20164551.
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    33. Joseph J, Cole G, Head E, Ingram D. Nutrition, brain aging, and neurodegeneration. J Neurosci. 2009 Oct 14; 29(41):12795-801. PMID: 19828791.
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    34. Christie LA, Opii WO, Head E, Araujo JA, de Rivera C, Milgram NW, Cotman CW. Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Exp Gerontol. 2009 Dec; 44(12):752-9. PMID: 19735717.
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    35. Head E, Nukala VN, Fenoglio KA, Muggenburg BA, Cotman CW, Sullivan PG. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Exp Neurol. 2009 Nov; 220(1):171-6. PMID: 19703441.
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    36. Tomic JL, Pensalfini A, Head E, Glabe CG. Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis. 2009 Sep; 35(3):352-8. PMID: 19523517.
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    37. Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head E. A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta Neuropathol. 2009 Oct; 118(4):505-17. PMID: 19360426.
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    38. Vasilevko V, Head E. Immunotherapy in a natural model of Abeta pathogenesis: the aging beagle. CNS Neurol Disord Drug Targets. 2009 Apr; 8(2):98-113. PMID: 19355931.
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    39. Berlau DJ, Corrada MM, Head E, Kawas CH. APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old. Neurology. 2009 Mar 3; 72(9):829-34. PMID: 19255410.
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    40. Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C. Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. J Biol Chem. 2009 Feb 13; 284(7):4230-7. PMID: 19098006.
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    41. Cotman CW, Head E. The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis. 2008 Dec; 15(4):685-707. PMID: 19096165.
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    42. Christie LA, Saunders RC, Kowalska DM, MacKay WA, Head E, Cotman CW. Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines. J Comp Neurol. 2008 Nov 10; 511(2):257-70. PMID: 18792072.
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    43. Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW. Gene expression changes in the course of normal brain aging are sexually dimorphic. Proc Natl Acad Sci U S A. 2008 Oct 7; 105(40):15605-10. PMID: 18832152.
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    44. Head E. Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging. Neurochem Res. 2009 Apr; 34(4):670-8. PMID: 18683046.
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    45. Christie LA, Opii WO, Head E. Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines. Age (Dordr). 2009 Sep; 31(3):211-20. PMID: 19714491.
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    46. Rohn TT, Head E. Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase? Int J Clin Exp Pathol. 2009; 2(2):108-18. PMID: 19079646.
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    47. Head E, Pop V, Vasilevko V, Hill M, Saing T, Sarsoza F, Nistor M, Christie LA, Milton S, Glabe C, Barrett E, Cribbs D. A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. J Neurosci. 2008 Apr 2; 28(14):3555-66. PMID: 18385314.
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    48. Rohn TT, Vyas V, Hernandez-Estrada T, Nichol KE, Christie LA, Head E. Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2. J Neurosci. 2008 Mar 19; 28(12):3051-9. PMID: 18354008.
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    49. Rohn TT, Head E. Caspase activation in Alzheimer's disease: early to rise and late to bed. Rev Neurosci. 2008; 19(6):383-93. PMID: 19317178.
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    50. Head E, Rofina J, Zicker S. Oxidative stress, aging, and central nervous system disease in the canine model of human brain aging. Vet Clin North Am Small Anim Pract. 2008 Jan; 38(1):167-78, vi. PMID: 18249248.
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    51. Head E, Corrada MM, Kahle-Wrobleski K, Kim RC, Sarsoza F, Goodus M, Kawas CH. Synaptic proteins, neuropathology and cognitive status in the oldest-old. Neurobiol Aging. 2009 Jul; 30(7):1125-34. PMID: 18006193.
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    52. Petrushina I, Ghochikyan A, Mktrichyan M, Mamikonyan G, Movsesyan N, Davtyan H, Patel A, Head E, Cribbs DH, Agadjanyan MG. Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. J Neurosci. 2007 Nov 14; 27(46):12721-31. PMID: 18003852.
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    53. Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener. 2007; 2:18. PMID: 17897471.
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    54. Head E. Combining an antioxidant-fortified diet with behavioral enrichment leads to cognitive improvement and reduced brain pathology in aging canines: strategies for healthy aging. Ann N Y Acad Sci. 2007 Oct; 1114:398-406. PMID: 17717087.
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    55. Berlau DJ, Kahle-Wrobleski K, Head E, Goodus M, Kim R, Kawas C. Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype. Arch Neurol. 2007 Aug; 64(8):1193-6. PMID: 17698712.
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    56. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol Learn Mem. 2007 Sep; 88(2):249-59. PMID: 17587610.
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    57. Lott IT, Head E, Doran E, Busciglio J. Beta-amyloid, oxidative stress and down syndrome. Curr Alzheimer Res. 2006 Dec; 3(5):521-8. PMID: 17168651.
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    58. Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging. 2008 Jan; 29(1):39-50. PMID: 17092609.
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    59. Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging. 2008 Jan; 29(1):51-70. PMID: 17055614.
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    60. Milgram NW, Siwak-Tapp CT, Araujo J, Head E. Neuroprotective effects of cognitive enrichment. Ageing Res Rev. 2006 Aug; 5(3):354-69. PMID: 16949888.
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    61. Head E, Starr A, Kim RC, Parachikova A, Lopez GE, Dick M, Cribbs DH. Relapsing polychondritis with features of dementia with Lewy bodies. Acta Neuropathol. 2006 Aug; 112(2):217-25. PMID: 16832629.
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    62. Gunn-Moore DA, McVee J, Bradshaw JM, Pearson GR, Head E, Gunn-Moore FJ. Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits. J Feline Med Surg. 2006 Aug; 8(4):234-42. PMID: 16603401.
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    63. Studzinski CM, Christie LA, Araujo JA, Burnham WM, Head E, Cotman CW, Milgram NW. Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiol Learn Mem. 2006 Sep; 86(2):197-204. PMID: 16616528.
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    64. Mouser PE, Head E, Ha KH, Rohn TT. Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain. Am J Pathol. 2006 Mar; 168(3):936-46. PMID: 16507909.
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    65. Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 2006 Apr 5; 24(15):2824-34. PMID: 16460841.
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    66. Tapp PD, Head K, Head E, Milgram NW, Muggenburg BA, Su MY. Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging. Neuroimage. 2006 Jan 1; 29(1):234-44. PMID: 16275022.
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    67. Chubb C, Inagaki Y, Sheu P, Cummings B, Wasserman A, Head E, Cotman C. BioVision: an application for the automated image analysis of histological sections. Neurobiol Aging. 2006 Oct; 27(10):1462-76. PMID: 16271803.
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    68. Roudebush P, Zicker SC, Cotman CW, Milgram NW, Muggenburg BA, Head E. Nutritional management of brain aging in dogs. J Am Vet Med Assoc. 2005 Sep 1; 227(5):722-8. PMID: 16178393.
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    69. Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol. 2005 Aug; 110(2):135-44. PMID: 15986225.
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    70. Tapp PD, Chu Y, Araujo JA, Chiou JY, Head E, Milgram NW, Su MY. Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imaging to assess cerebral blood volume in a canine model of aging. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):399-406. PMID: 15795048.
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    71. Su MY, Tapp PD, Vu L, Chen YF, Chu Y, Muggenburg B, Chiou JY, Chen C, Wang J, Bracco C, Head E. A longitudinal study of brain morphometrics using serial magnetic resonance imaging analysis in a canine model of aging. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):389-97. PMID: 15795047.
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    72. Nelson L, Johnson JK, Freedman M, Lott I, Groot J, Chang M, Milgram NW, Head E. Learning and memory as a function of age in Down syndrome: a study using animal-based tasks. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):443-53. PMID: 15795053.
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    73. Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW. Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):461-9. PMID: 15795055.
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    74. Lott IT, Head E. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol Aging. 2005 Mar; 26(3):383-9. PMID: 15639317.
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    75. Christie LA, Studzinski CM, Araujo JA, Leung CS, Ikeda-Douglas CJ, Head E, Cotman CW, Milgram NW. A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar; 29(3):361-9. PMID: 15795044.
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    76. Thomas SN, Soreghan BA, Nistor M, Sarsoza F, Head E, Yang AJ. Reduced neuronal expression of synaptic transmission modulator HNK-1/neural cell adhesion molecule as a potential consequence of amyloid beta-mediated oxidative stress: a proteomic approach. J Neurochem. 2005 Feb; 92(4):705-17. PMID: 15686472.
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    77. Liu J, Head E, Kuratsune H, Cotman CW, Ames BN. Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci. 2004 Nov; 1033:117-31. PMID: 15591009.
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    78. Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su MY. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci. 2004 Sep 22; 24(38):8205-13. PMID: 15385603.
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    79. Tapp PD, Siwak CT, Head E, Cotman CW, Murphey H, Muggenburg BA, Ikeda-Douglas C, Milgram NW. Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behav Brain Res. 2004 Aug 12; 153(1):199-210. PMID: 15219721.
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    80. Milgram NW, Head E, Zicker SC, Ikeda-Douglas C, Murphey H, Muggenberg BA, Siwak CT, Tapp PD, Lowry SR, Cotman CW. Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Exp Gerontol. 2004 May; 39(5):753-65. PMID: 15130670.
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    81. Head E, Lott IT. Down syndrome and beta-amyloid deposition. Curr Opin Neurol. 2004 Apr; 17(2):95-100. PMID: 15021233.
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    82. Head E, Zicker SC. Nutraceuticals, aging, and cognitive dysfunction. Vet Clin North Am Small Anim Pract. 2004 Jan; 34(1):217-28. PMID: 15032129.
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    83. Johnson JK, Vogt BA, Kim R, Cotman CW, Head E. Isolated executive impairment and associated frontal neuropathology. Dement Geriatr Cogn Disord. 2004; 17(4):360-7. PMID: 15178954.
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    84. Zhao M, Su J, Head E, Cotman CW. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol Dis. 2003 Dec; 14(3):391-403. PMID: 14678756.
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    85. Nippak PM, Chan AD, Campbell Z, Muggenburg B, Head E, Ikeda-Douglas CJ, Murphey H, Cotman CW, Milgram NW. Response latency in Canis familiaris: mental ability or mental strategy? Behav Neurosci. 2003 Oct; 117(5):1066-75. PMID: 14570555.
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    86. Bi X, Head E, Cotman CW, Lynch G. Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease. J Comp Neurol. 2003 Sep 22; 464(3):371-81. PMID: 12900930.
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    87. Siwak CT, Tapp PD, Zicker SC, Murphey HL, Muggenburg BA, Head E, Cotman CW, Milgram NW. Locomotor activity rhythms in dogs vary with age and cognitive status. Behav Neurosci. 2003 Aug; 117(4):813-24. PMID: 12931965.
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    88. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003 Apr 18; 300(5618):486-9. PMID: 12702875.
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    89. Tapp PD, Siwak CT, Estrada J, Head E, Muggenburg BA, Cotman CW, Milgram NW. Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem. 2003 Jan-Feb; 10(1):64-73. PMID: 12551965.
      View in: PubMed
    90. Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiol Dis. 2002 Nov; 11(2):341-54. PMID: 12505426.
      View in: PubMed
    91. Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann N Y Acad Sci. 2002 Nov; 977:45-64. PMID: 12480733.
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    92. Head E, Lott IT, Cribbs DH, Cotman CW, Rohn TT. Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neurosci Lett. 2002 Sep 13; 330(1):99-103. PMID: 12213643.
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    93. Cotman CW, Head E, Muggenburg BA, Zicker S, Milgram NW. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging. 2002 Sep-Oct; 23(5):809-18. PMID: 12392784.
      View in: PubMed
    94. Chan AD, Nippak PM, Murphey H, Ikeda-Douglas CJ, Muggenburg B, Head E, Cotman CW, Milgram NW. Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behav Neurosci. 2002 Jun; 116(3):443-54. PMID: 12049325.
      View in: PubMed
    95. Su JH, Kesslak JP, Head E, Cotman CW. Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathol. 2002 Jul; 104(1):1-6. PMID: 12070657.
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    96. Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2356-61. PMID: 11854529.
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    97. Head E, Torp R. Insights into Abeta and presenilin from a canine model of human brain aging. Neurobiol Dis. 2002 Feb; 9(1):1-10. PMID: 11848680.
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    98. Head ES, Macdonald EM, Ewert A, Apisarnthanarax P. Sarcoptes scabiei in histopathologic sections of skin in human scabies. Arch Dermatol. 1990 Nov; 126(11):1475-7. PMID: 2122813.
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    99. Tschen E, Head ES, Macdonald E. Dual infection of the toe web caused by Trichophyton rubrum and Microsporum canis. J Med Vet Mycol. 1986 Oct; 24(5):423-5. PMID: 3783364.
      View in: PubMed
    100. Hebert AA, Head ES, Macdonald EM. Tinea capitis caused by Trichophyton tonsurans. Pediatr Dermatol. 1985 Mar; 2(3):219-23. PMID: 3991377.
      View in: PubMed
    101. Head ES, Henry JC, Macdonald EM. The cotton swab technic for the culture of dermatophyte infections--its efficacy and merit. J Am Acad Dermatol. 1984 Nov; 11(5 Pt 1):797-801. PMID: 6392360.
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    102. Subrt P, Jorizzo JL, Apisarnthanarax P, Head ES, Smith EB. Spreading pigmented actinic keratosis. J Am Acad Dermatol. 1983 Jan; 8(1):63-7. PMID: 6826809.
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