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Charles Smith

Address740 S Limestone St
L445 KENTUCKY CLINIC
LEXINGTON KY 405360284
Phone8593236702
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gold BT, Kim C, Johnson NF, Kryscio RJ, Smith CD. Lifelong bilingualism maintains neural efficiency for cognitive control in aging. J Neurosci. 2013 Jan 9; 33(2):387-96. PMID: 23303919.
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    2. Gao P, Peterson YK, Smith RA, Smith CD. Characterization of isoenzyme-selective inhibitors of human sphingosine kinases. PLoS One. 2012; 7(9):e44543. PMID: 22970244.
      View in: PubMed
    3. Liu Q, Rehman H, Shi Y, Krishnasamy Y, Lemasters JJ, Smith CD, Zhong Z. Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. PLoS One. 2012; 7(7):e41834. PMID: 22848628.
      View in: PubMed
    4. Abner EL, Kryscio RJ, Cooper GE, Fardo DW, Jicha GA, Mendiondo MS, Nelson PT, Smith CD, Van Eldik LJ, Wan L, Schmitt FA. Mild cognitive impairment: statistical models of transition using longitudinal clinical data. Int J Alzheimers Dis. 2012; 2012:291920. PMID: 22536535.
      View in: PubMed
    5. Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A. 2012 Mar 6; 109(10):3985-90. PMID: 22343285.
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    6. Andersen AH, Rayens WS, Liu Y, Smith CD. Partial least squares for discrimination in fMRI data. Magn Reson Imaging. 2012 Apr; 30(3):446-52. PMID: 22227352.
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    7. Smith CD, Andersen AH, Gold BT. Structural brain alterations before mild cognitive impairment in ADNI: validation of volume loss in a predefined antero-temporal region. J Alzheimers Dis. 2012; 31 Suppl 3:S49-58. PMID: 22460332.
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    8. Gold BT, Jiang Y, Powell DK, Smith CD. Multimodal imaging evidence for axonal and myelin deterioration in amnestic mild cognitive impairment. J Alzheimers Dis. 2012; 31 Suppl 3:S19-31. PMID: 22460327.
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    9. Gold BT, Johnson NF, Powell DK, Smith CD. White matter integrity and vulnerability to Alzheimer's disease: preliminary findings and future directions. Biochim Biophys Acta. 2012 Mar; 1822(3):416-22. PMID: 21803153.
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    10. Smith CD. Structural imaging in early pre-states of dementia. Biochim Biophys Acta. 2012 Mar; 1822(3):317-24. PMID: 21777674.
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    11. Nelson PT, Schmitt FA, Lin Y, Abner EL, Jicha GA, Patel E, Thomason PC, Neltner JH, Smith CD, Santacruz KS, Sonnen JA, Poon LW, Gearing M, Green RC, Woodard JL, Van Eldik LJ, Kryscio RJ. Hippocampal sclerosis in advanced age: clinical and pathological features. Brain. 2011 May; 134(Pt 5):1506-18. PMID: 21596774.
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    12. Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathol. 2011 May; 121(5):571-87. PMID: 21516511.
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    13. Jicha GA, Abner EL, Schmitt FA, Kryscio RJ, Riley KP, Cooper GE, Stiles N, Mendiondo MS, Smith CD, Van Eldik LJ, Nelson PT. Preclinical AD Workgroup staging: pathological correlates and potential challenges. Neurobiol Aging. 2012 Mar; 33(3):622.e1-622.e16. PMID: 21507528.
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    14. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. PMID: 21460841.
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    15. Riley KP, Jicha GA, Davis D, Abner EL, Cooper GE, Stiles N, Smith CD, Kryscio RJ, Nelson PT, Van Eldik LJ, Schmitt FA. Prediction of preclinical Alzheimer's disease: longitudinal rates of change in cognition. J Alzheimers Dis. 2011; 25(4):707-17. PMID: 21498903.
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    16. Abner EL, Kryscio RJ, Schmitt FA, Santacruz KS, Jicha GA, Lin Y, Neltner JM, Smith CD, Van Eldik LJ, Nelson PT. "End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction? J Alzheimers Dis. 2011; 25(3):445-53. PMID: 21471646.
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    17. Threlkeld ZD, Jicha GA, Smith CD, Gold BT. Task deactivation reductions and atrophy within parietal default mode regions are overlapping but only weakly correlated in mild cognitive impairment. J Alzheimers Dis. 2011; 27(2):415-27. PMID: 21860094.
      View in: PubMed
    18. Gold BT, Jiang Y, Jicha GA, Smith CD. Functional response in ventral temporal cortex differentiates mild cognitive impairment from normal aging. Hum Brain Mapp. 2010 Aug; 31(8):1249-59. PMID: 20063353.
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    19. Nelson PT, Schmitt FA, Jicha GA, Kryscio RJ, Abner EL, Smith CD, Van Eldik LJ, Markesbery WR. Association between male gender and cortical Lewy body pathology in large autopsy series. J Neurol. 2010 Nov; 257(11):1875-81. PMID: 20563821.
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    20. Gold BT, Powell DK, Andersen AH, Smith CD. Alterations in multiple measures of white matter integrity in normal women at high risk for Alzheimer's disease. Neuroimage. 2010 Oct 1; 52(4):1487-94. PMID: 20493952.
      View in: PubMed
    21. Xia Z, Draper JM, Smith CD. Improved synthesis of a fluorogenic ceramidase substrate. Bioorg Med Chem. 2010 Feb; 18(3):1003-9. PMID: 20085856.
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    22. Smith CD. Neuroimaging through the course of Alzheimer's disease. J Alzheimers Dis. 2010; 19(1):273-90. PMID: 20061644.
      View in: PubMed
    23. Nelson PT, Jicha GA, Kryscio RJ, Abner EL, Schmitt FA, Cooper G, Xu LO, Smith CD, Markesbery WR. Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol. 2010 Mar; 257(3):359-66. PMID: 19795154.
      View in: PubMed
    24. Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Santacruz K, Smith CD, Patel E, Markesbery WR. Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease. J Neuropathol Exp Neurol. 2009 Jul; 68(7):774-84. PMID: 19535994.
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    25. Smith CD, Lori NF, Akbudak E, Sorar E, Gultepe E, Shimony JS, McKinstry RC, Conturo TE. MRI diffusion tensor tracking of a new amygdalo-fusiform and hippocampo-fusiform pathway system in humans. J Magn Reson Imaging. 2009 Jun; 29(6):1248-61. PMID: 19418556.
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    26. Price JL, McKeel DW, Buckles VD, Roe CM, Xiong C, Grundman M, Hansen LA, Petersen RC, Parisi JE, Dickson DW, Smith CD, Davis DG, Schmitt FA, Markesbery WR, Kaye J, Kurlan R, Hulette C, Kurland BF, Higdon R, Kukull W, Morris JC. Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging. 2009 Jul; 30(7):1026-36. PMID: 19376612.
      View in: PubMed
    27. Gold BT, Andersen AH, Jicha GA, Smith CD. Aging influences the neural correlates of lexical decision but not automatic semantic priming. Cereb Cortex. 2009 Nov; 19(11):2671-9. PMID: 19273460.
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    28. Nelson PT, Abner EL, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Davis DG, Poduska JW, Patel E, Mendiondo MS, Markesbery WR. Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons. Brain Pathol. 2010 Jan; 20(1):66-79. PMID: 19021630.
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    29. Nelson PT, Abner EL, Scheff SW, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Patel E, Markesbery WR. Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment. Neurosci Lett. 2009 Feb 6; 450(3):336-9. PMID: 19010392.
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    30. Conturo TE, Williams DL, Smith CD, Gultepe E, Akbudak E, Minshew NJ. Neuronal fiber pathway abnormalities in autism: an initial MRI diffusion tensor tracking study of hippocampo-fusiform and amygdalo-fusiform pathways. J Int Neuropsychol Soc. 2008 Nov; 14(6):933-46. PMID: 18954474.
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    31. Martin SB, Smith CD, Collins HR, Schmitt FA, Gold BT. Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment. Neurobiol Aging. 2010 Jul; 31(7):1099-106. PMID: 18809227.
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    32. Smith CD, Chebrolu H, Andersen AH, Powell DA, Lovell MA, Xiong S, Gold BT. White matter diffusion alterations in normal women at risk of Alzheimer's disease. Neurobiol Aging. 2010 Jul; 31(7):1122-31. PMID: 18801597.
      View in: PubMed
    33. Danner DD, Smith CD, Jessa P, Hudson J. African Americans with memory loss: findings from a community clinic in Lexington, Kentucky. Nurs Clin North Am. 2008 Sep; 43(3):437-47, ix-x. PMID: 18674674.
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    34. Liu X, Steinmetz NA, Farley AB, Smith CD, Joseph JE. Mid-fusiform activation during object discrimination reflects the process of differentiating structural descriptions. J Cogn Neurosci. 2008 Sep; 20(9):1711-26. PMID: 18345986.
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    35. Nelson PT, Smith CD, Abner EA, Schmitt FA, Scheff SW, Davis GJ, Keller JN, Jicha GA, Davis D, Wang-Xia W, Hartman A, Katz DG, Markesbery WR. Human cerebral neuropathology of Type 2 diabetes mellitus. Biochim Biophys Acta. 2009 May; 1792(5):454-69. PMID: 18789386.
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    36. Gold BT, Powell DK, Xuan L, Jicha GA, Smith CD. Age-related slowing of task switching is associated with decreased integrity of frontoparietal white matter. Neurobiol Aging. 2010 Mar; 31(3):512-22. PMID: 18495298.
      View in: PubMed
    37. Kimonis VE, Mehta SG, Fulchiero EC, Thomasova D, Pasquali M, Boycott K, Neilan EG, Kartashov A, Forman MS, Tucker S, Kimonis K, Mumm S, Whyte MP, Smith CD, Watts GD. Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia. Am J Med Genet A. 2008 Mar 15; 146A(6):745-57. PMID: 18260132.
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    38. Smith CD, Walton A, Slevin JT, Gerhardt GA, Umberger G, Smoot K, Schulze E, Gash D. Validation studies of the human movement analysis panel for hand/arm performance. J Neurosci Methods. 2007 Sep 30; 165(2):287-96. PMID: 17651810.
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    39. Martin SB, Covell DJ, Joseph JE, Chebrolu H, Smith CD, Kelly TH, Jiang Y, Gold BT. Human experience seeking correlates with hippocampus volume: convergent evidence from manual tracing and voxel-based morphometry. Neuropsychologia. 2007 Sep 20; 45(12):2874-81. PMID: 17603086.
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    40. Slevin JT, Gash DM, Smith CD, Gerhardt GA, Kryscio R, Chebrolu H, Walton A, Wagner R, Young AB. Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal. J Neurosurg. 2007 Apr; 106(4):614-20. PMID: 17432712.
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    41. Neumann M, Mackenzie IR, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS. TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol. 2007 Feb; 66(2):152-7. PMID: 17279000.
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    42. Mehta SG, Watts GD, Adamson JL, Hutton M, Umberger G, Xiong S, Ramdeen S, Lovell MA, Kimonis VE, Smith CD. APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD). Genet Med. 2007 Jan; 9(1):9-13. PMID: 17224685.
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    43. Espinosa PS, Smith CD, Berger JR. Alien hand syndrome. Neurology. 2006 Dec 26; 67(12):E21. PMID: 17190927.
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    44. Espinosa PS, Smith CD, Berger JR. Homonymous hemianopsia complicating treatment of postoperative epistaxis. Neurology. 2006 Oct 10; 67(7):1305. PMID: 17030776.
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    45. Ritter EM, McClusky DA, Gallagher AG, Enochsson L, Smith CD. Perceptual, visuospatial, and psychomotor abilities correlate with duration of training required on a virtual-reality flexible endoscopy simulator. Am J Surg. 2006 Sep; 192(3):379-84. PMID: 16920434.
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    46. Gold BT, Balota DA, Jones SJ, Powell DK, Smith CD, Andersen AH. Dissociation of automatic and strategic lexical-semantics: functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions. J Neurosci. 2006 Jun 14; 26(24):6523-32. PMID: 16775140.
      View in: PubMed
    47. Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Markesbery WR. Age and gender effects on human brain anatomy: a voxel-based morphometric study in healthy elderly. Neurobiol Aging. 2007 Jul; 28(7):1075-87. PMID: 16774798.
      View in: PubMed
    48. Forman MS, Mackenzie IR, Cairns NJ, Swanson E, Boyer PJ, Drachman DA, Jhaveri BS, Karlawish JH, Pestronk A, Smith TW, Tu PH, Watts GD, Markesbery WR, Smith CD, Kimonis VE. Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations. J Neuropathol Exp Neurol. 2006 Jun; 65(6):571-81. PMID: 16783167.
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    49. Slevin JT, Gerhardt GA, Smith CD, Gash DM, Young AB. Reply: GDNF poses troubling questions for doctors, drug maker. Ann Neurol. 2006 Jun; 59(6):989-90. PMID: 16718700.
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    50. Slevin JT, Gash DM, Smith CD, Gerhardt GA, Kryscio R, Chebrolu H, Walton A, Wagner R, Young AB. Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal. Neurosurg Focus. 2006; 20(5):E1. PMID: 16711657.
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    51. Espinosa PS, Kryscio RJ, Mendiondo MS, Schmitt FA, Wekstein DR, Markesbery WR, Smith CD. Alzheimer's disease and head circumference. J Alzheimers Dis. 2006 Mar; 9(1):77-80. PMID: 16627937.
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    52. Markesbery WR, Schmitt FA, Kryscio RJ, Davis DG, Smith CD, Wekstein DR. Neuropathologic substrate of mild cognitive impairment. Arch Neurol. 2006 Jan; 63(1):38-46. PMID: 16401735.
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    53. Smith CD, Wekstein DR, Markesbery WR, Frye CA. 3alpha,5alpha-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia. Psychopharmacology (Berl). 2006 Jun; 186(3):481-5. PMID: 16231167.
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    54. Riel-Romero RM, Baumann RJ, Smith CD. An unusual complication of cancer treatment for acute lymphoblastic leukemia. J Neurooncol. 2005 Jul; 73(3):269-72. PMID: 15980979.
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    55. Riel-Romero RM, Smith CD, Pettigrew AL. Megalencephalic leukoencephalopathy with subcortical cysts in two siblings owing to two novel mutations: case reports and review of the literature. J Child Neurol. 2005 Mar; 20(3):230-4. PMID: 15832614.
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    56. Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, Young B. Research on Parkinson disease. J Neurosurg. 2005 Feb; 102(2):401. PMID: 15739575.
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    57. Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, Young B. Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor. J Neurosurg. 2005 Feb; 102(2):216-22. PMID: 15739547.
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    58. Gaugler JE, Anderson KA, Leach MS, Smith CD, Schmitt FA, Mendiondo M. The emotional ramifications of unmet need in dementia caregiving. Am J Alzheimers Dis Other Demen. 2004 Nov-Dec; 19(6):369-80. PMID: 15633946.
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    59. Blonder LX, Smith CD, Davis CE, Kesler-West ML, Garrity TF, Avison MJ, Andersen AH. Regional brain response to faces of humans and dogs. Brain Res Cogn Brain Res. 2004 Aug; 20(3):384-94. PMID: 15268916.
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    60. Gaugler JE, Mendiondo M, Smith CD, Schmitt FA. Secondary dementia caregiving and its consequences. Am J Alzheimers Dis Other Demen. 2003 Sep-Oct; 18(5):300-8. PMID: 14569647.
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    61. Baker RS, Andersen AH, Morecraft RJ, Smith CD. A functional magnetic resonance imaging study in patients with benign essential blepharospasm. J Neuroophthalmol. 2003 Mar; 23(1):11-5. PMID: 12616082.
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    62. Gaugler JE, Wackerbarth SB, Mendiondo M, Schmitt FA, Smith CD. The characteristics of dementia caregiving onset. Am J Alzheimers Dis Other Demen. 2003 Mar-Apr; 18(2):97-104. PMID: 12708225.
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    63. Robertson WC, Smith CD. Sydenham's chorea in the age of MRI: a case report and review. Pediatr Neurol. 2002 Jul; 27(1):65-7. PMID: 12160978.
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    64. Smith CD. Serial MRI findings in a case of primary lateral sclerosis. Neurology. 2002 Feb 26; 58(4):647-9. PMID: 11865149.
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